HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-quinuclidin-3-yl 2-amino-2-(4-chlorophenyl)acetate dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 67607091 | HCID 67607091 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (R)-quinuclidin-3-yl 2-amino-2-(4-chlorophenyl)acetate dihydrochloride | HCID 67606496 | 201.2% |
Reaction Steps
To a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)acetate (C47) (250 mg, 0.63 mmol) in THF (5 ml), was added 37% hydrogen chloride (1.0 ml, 12.2 mmol). The reaction was stirred at RT for 15 hours. The solvent was evaporated to obtain (R)-quinuclidin-3-yl 2-amino-2-(4-chlorophenyl)acetate dihydrochloride (233 mg; quantitative yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772314B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6a1d0cf34e754c83919fda15648de8fb |
| Source note | uspto-grants-2014_07 |