2-Chloroacetophenone → HCID 86665856, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (43.0 mg, 0.28 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(thiophen-2-yl)acetate (102 mg, 0.28 mmol) in EtOAc (3 ml). The reaction was stirred at RT for 20 hours. The solvent was evaporated, and the crude was triturated with Et2O (2 ml) and dried under vacuum to obtain (3R)-3-(2-(tert-butoxycarbonylamino)-2-(thiophen-2-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (70 mg, 48.3% yield).

Provenance & Evidence