Phenacyl bromide → HCID 86665860, compound

Participants

Reaction Steps

To a solution of (S)—((R)-quinuclidin-3-yl) 3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate (590 mg, 1.23 mmol) in EtOAc (15 ml), was added portionwise 2-bromo-1-phenylethanone (232 mg, 1.17 mmol). The reaction was stirred at RT for 16 hours. The solvent was evaporated, and the residue was triturated with Et2O, filtered and dried under vacuum to obtain (R)-3-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoyloxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (720 mg, 86% yield).

Provenance & Evidence