HCID 86665860, compound → HCID 67607403, compound

Participants

Reaction Steps

A mixture of (R)-3-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)-propanoyloxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (720 mg, 1.06 mmol) and 10% Pd/C (100 mg, 0.09 mmol) in MeOH (30 ml) was hydrogenated at 25 psi for 2 hours. The catalyst was removed by filtration, and the solvent was evaporated to dryness. The residue was dissolved in DCM and filtered through a SCX cartridge. The solution was evaporated to obtain (S)—((R)-quinuclidin-3-yl) 2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanoate (260 mg, 62.9% yield).

Provenance & Evidence