Hydrochloric Acid → HCID 56600581, compound

Participants

Reaction Steps

A mixture of 3-Chloro-N-(methoxymethyl)-N-pyridazin-3-yl-4-{[3-pyridazin-4-yl-4′-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide and 3-chloro-N-[(3E)-2-(methoxymethyl)pyridazin-3(2H)-ylidene]-4-{[3-pyridazin-4-yl-4′-(trifluoromethyl)biphenyl-4-yl]oxy}benzenesulfonamide (Preparation 49, 85 mg, 0.13 mmol) were dissolved in dichloromethane (1 mL) and a 4M solution of hydrogen chloride in 1,4-dioxane (0.34 mL) added. The mixture was stirred at room temperature for 15 minutes. The reaction mixture was concentrated in vacuo and the resulting residue purified by reverse phase preparative HPLC (Trilution method) to afford the title compound as a white solid (26 mg, 33%).

Provenance & Evidence