3-Cyano-N-(2,4-dimethoxybenzyl)-4-{[3-pyridazin-4-yl-2'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide → HCID 56601185, compound

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Reaction Steps

3-Cyano-N-(2,4-dimethoxybenzyl)-4-{[3-pyridazin-4-yl-2′-(trifluoromethyl)biphenyl-4-yl]oxy}-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 21, 400 mg, 0.55 mmol) was dissolved in a 4M solution of HCl in 1,4-dioxane (9 mL). The mixture was stirred at room temperature for 2 hours and then concentrated in vacuo. The residue was purified by silica gel column chromatography (0%-15% methanol in dichloromethane gradient elution), followed by trituration in tert-butylmethyl ether. The residue was purified further by a silica plug column (0%-20% methanol in dichloromethane) to afford the title compound (73 mg, 23%) as a white solid.

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