HCID 66653628, compound → HCID 56601580, compound

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The crude 5-chloro-4-(2-chloro-2′-fluoro-5-(pyridazin-4-yl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide (220 mg) was dissolved in a 4M solution of HCl in 1,4-dioxane (10 mL) and stirred at room temperature for 3 hours. The resulting precipitate was collected and purified by reverse phase chromatography using acetonitrile:water:0.05% formic acid followed by chromatography on silica gel eluting with dichloromethane/methanol 9:1 to give the title compound (8.5 mg, 3.5%) as a white solid.

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