HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → HCID 136200892, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 6-bromo-4H-chromen-4-one | HCID 548522 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 136200892 | HCID 136200892 | 44.6% |
Reaction Steps
To a suspension of 6-bromochromone (1.58 g, 0.0070 mol) in ethanol (30 mL) was added methylhydrazine (0.41 mL, 0.0077 mol) and boron trifluoride etherate (1.15 mL, 0.0091 mol). The reaction was heated to reflux for 22 hours. After cooling, the reaction was concentrated in vacuo and the residue purified by automated flash column chromatography using a 0-100% ethyl acetate/hexanes gradient. This provided the title compound (0.79 g, 44%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772293B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1894b90a44964114a499aa094415f0bf |
| Source note | uspto-grants-2014_07 |