Diethyl Ether → HCID 73083080, compound

Participants

Reaction Steps

A solution of N-chlorosuccinimide (2.24 g, 16.6 mmol) in abs. DMF (11 ml) was added to a solution of compound Z (2.06 g, 13.8 mmol) in abs. DMF (10 ml) at a temperature of 30-40° C. within 20 min. Cooling in an ice bath was carried out if necessary. The reaction mixture was stirred for 3 h at RT and then mixed with diethyl ether (120 ml) and water (80 ml). The phases were separated. The aqueous phase was extracted with diethyl ether (2×50 ml). The combined organic extracts were washed successively with water (80 ml) and sat. NaCl solution (100 ml). The organic phase was dried and concentrated. 3-phenyl propanehydroximoyl chloride was obtained as a light green oil (2.47 g) and immediately reacted further.

Provenance & Evidence