Bromine → HCID 67464434, compound

HRID 1619916Notes

Reaction equation

HRID 1619916 reaction equation
[CH3:1][C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[Na+].[Br:22]Br>C(O)(=O)C>[Br:22][C:3]1[CH:4]=[CH:5][C:6]2[N:7]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:9][C:10]=2[C:2]=1[CH3:1]

Participants

5

Reactant 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 59679596HCID 59679596, compound

Product 1

HCID 67464434HCID 67464434, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.55 g (7.41 mmol) 7-methyl-2-phenyl-benzoxazole are dissolved in 5 ml glacial acetic acid, then 0.74 g (9.02 mmol) sodium acetate and 1.25 g (7.82 mmol) bromine are added. The mixture is stirred overnight at RT, then the solv. is eliminated by rotary evaporation in vacuo, the residue is dissolved with petroleum ether and extracted with water. The org. phase is dried on magnesium sulphate and evaporated down to ¼. The precipitated solid is suction filtered cold.

Workup

  1. customis eliminated by rotary evaporation in vacuo
  2. dissolutionthe residue is dissolved with petroleum ether
  3. extractionextracted with water
  4. customphase is dried on magnesium sulphate
  5. customevaporated down

Sources & evidence

ORD record
ord-07a7b4aca3fb4453ab0d94a8b2cfc7f2
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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