HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-benzylamino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one → 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-benzylamino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one | HCID 67464695 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one | HCID 67462851 | — |
Reaction Steps
2.20 g (6.52 mmol) 6-(4-benzylamino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one, 120 mg 10% Pd/C and 20 mL MeOH are hydrogenated for 2 h at 3 bar H2. The reaction mixture is concentrated by rotary evaporation i. V. and the residue is crystallised with acetonitrile/diethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1a1380be7ccb494981d4b4b282da17ee |
| Source note | uspto-grants-2014_07 |