MeOH water TFA → cis-6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one

HRID 1619936Notes

Reaction equation

HRID 1619936 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH2:16][CH3:17])[CH:10]([CH3:15])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[OH:18].CO.O.C(O)(C(F)(F)F)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@H:9]([CH2:16][CH3:17])[C@H:10]([CH3:15])[C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[OH:18]

Participants

3

Reactant 2

HCID 21999908MeOH water TFAHCID 674628516-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one

Product 1

HCID 67462853cis-6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one

Procedure

1.10 g (4.45 mmol) 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4-methyl-4,5-dihydro-2H-pyridazin-3-one are separated by RP (xBridge, MeOH/H2O/TFA).

Sources & evidence

ORD record
ord-c1a3529572eb466eaa21faa049adb875
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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