6-Bromo-2-phenylbenzo[d]oxazole → (R)-3-methoxy-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid

HRID 1619942Notes

Reaction equation

HRID 1619942 reaction equation
Br[C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[O:8][C:4]=2[CH:3]=1.[CH3:17][O:18][C@@H:19]1[CH2:23][C:22](=[O:24])[O:21][C:20]1=[O:25]>>[CH3:17][O:18][C@@H:19]([C:20](=[O:25])[C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[O:8][C:4]=2[CH:3]=1)[CH2:23][C:22]([OH:24])=[O:21]

Participants

3

Reactant 2

HCID 230259476-Bromo-2-phenylbenzo[d]oxazoleHCID 86689062(R)-3-methoxy-dihydro-furan-2,5-dione

Product 1

HCID 67464500(R)-3-methoxy-4-oxo-4-(2-phenyl-benzoxazol-6-yl)-butyric acid

Procedure

The preparation is carried out analogously to Example 1a from 6-bromo-2-phenyl-benzoxazole and (R)-3-methoxy-dihydro-furan-2,5-dione.

Sources & evidence

ORD record
ord-1849199a631b42ab97e50faebe422271
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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