反应详情

27 mg (69 μmol) 5-ethyl-6-{2-[4-(2-oxo-propoxy)-phenyl]-benzoxazol-6-yl}-4,5-dihydro-2H pyridazin-3-one are placed in 5 mL EtOH, 5.5 mg (145 μmol) sodium borohydride are added with cooling and the mixture is stirred for 3 h at RT. The reaction mixture is added to 50 mL ice water and extracted with DCM. The org. phase is washed with sat. saline solution and then the solv. is totally eliminated i.V. The residue is crystallised from cyclohexane/EA.

1. temperaturewith cooling
2. extractionextracted with DCM
3. washphase is washed with sat. saline solution
4. customThe residue is crystallised from cyclohexane/EA