HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1619965Generated: October 31, 2026
Hydrochloric Acid → 4-(4-Benzylamino-3-hydroxy-phenyl)-3-methyl-4-oxo-butyric acid
https://huagongshe.com/reaction/1619965
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 2-(2-Hydroxyethoxy)ethanol;methoxymethane | HCID 21225657 | — |
| Reactant | 2-[2-(4-Benzylamino-3-hydroxy-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid | HCID 67467030 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Benzylamino-3-hydroxy-phenyl)-3-methyl-4-oxo-butyric acid | HCID 67466177 | — |
Reaction Steps
78.9 g (220.8 mmol) 2-[2-(4-benzylamino-3-hydroxy-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid are combined with 200 ml diethyleneglycol-dimethylether and stirred for 3 h at 140° C. The mixture is combined with water and diisopropylether, then it is adjusted with 6N hydrochloric acid to pH=2 and extracted with DCM. The org. phase is separated off and dried on magnesium sulphate, then the solv. is eliminated by rotary evaporation i.V., the residue is stirred with diisopropylether and filtered off.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08772323B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-c9736f84cf7f46008f3683e08e20853f |
|---|
| Source note | uspto-grants-2014_07 |
|---|
