HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-ethyl-6-[2-(2-fluoro-4-methoxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-Fluoro-4-methoxybenzoyl chloride | HCID 14484714 | — |
| Reactant | 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4,5-dihydro-2H-pyridazin-3-one | HCID 67461254 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 5-ethyl-6-[2-(2-fluoro-4-methoxy-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one | HCID 67466315 | — |
Reaction Steps
200 mg (857 μmol) 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4,5-dihydro-2H-pyridazin-3-one are refluxed together with 170 mg (901 μmol) 2-fluoro-4-methoxybenzoyl chloride, 70 mg (885 μmol) pyridine, 160 mg (841 μmol) para-toluenesulphonic acid monohydrate and 5 ml xylene for 4 h. The reaction mixture is evaporated down completely i.V. and the residue is crystallised from acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-81b9a590de764929b0e97cdd467f2d72 |
| Source note | uspto-grants-2014_07 |