HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1619970Generated: November 2, 2026
4-Isopropylbenzoyl chloride → 5-ethyl-6-[2-(4-isopropyl-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one
https://huagongshe.com/reaction/1619970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Isopropylbenzoyl chloride | HCID 2759486 | — |
| Reactant | 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4,5-dihydro-2H-pyridazin-3-one | HCID 67461254 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-ethyl-6-[2-(4-isopropyl-phenyl)-benzoxazol-6-yl]-4,5-dihydro-2H-pyridazin-3-one | HCID 67462519 | — |
Reaction Steps
200 mg (857 μmol) 6-(4-amino-3-hydroxy-phenyl)-5-ethyl-4,5-dihydro-2H-pyridazin-3-one are placed in 5 ml dioxane. 175 mg (958 μmol) 4-isopropyl-benzoyl chloride are added and the mixture is stirred for 15 min at 200° C. in the microwave. The solvent is eliminated by rotary evaporation in vacuo and the residue is separated through silica gel (eluant cyclohexane/EA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772323B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-6e50bf15a5e04921a660f68950a6f548 |
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| Source note | uspto-grants-2014_07 |
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