HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-2-pyrrolecarboxylic acid → HCID 67466941, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-2-pyrrolecarboxylic acid | HCID 81453 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67466183 | HCID 67466183 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67466941 | HCID 67466941 | — |
Reaction Steps
240 mg (1.92 mmol) 1-methyl-1H-pyrrol-2-carboxylic acid is placed in 20 mL DCM. 760 mg (2.00 mmol) HATU, 1.50 mL (8.76 mmol) DIPEA and 600 mg (2.30 mmol) 6-(4-amino-3-hydroxy-phenyl)-5-methyl-4-propyl-4,5-dihydro-2H-pyridazin-3-one are added and the mixture is stirred for 3 h at RT. The reaction mixture is extracted successively with 0.5% acetic acid, 10% sodium carbonate solution and saline solution. Then the organic phase is dried and the solv. is eliminated i.V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d18e2d88031a4b4886977d95c9863671 |
| Source note | uspto-grants-2014_07 |