HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 54591572, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 67466265 | HCID 67466265 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 54591572 | HCID 54591572 | — |
Reaction Steps
25 mg (69 μmol) methyl 4-[6-(4-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzoxazol-2-yl]-benzoate is placed in 4 mL DMSO, 350 μL (1 mmol/mL; 346 μmol) sodium hydroxide solution are added and the mixture is stirred overnight at RT. The reaction mixture is adjusted to pH 4 with 10% citric acid and extracted with H2O and DCM. Then the solv. of the organic phase is eliminated i.V. and the residue is separated by HPLC-MS. (xTerra, ACN/H2O+TFA)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-ec023d17cf0a48d2a91c52e0f806cfa1 |
| Source note | uspto-grants-2014_07 |