Ethanol → 6-[2-(2-chloro-6-morpholin-4-yl-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

HRID 1619979Notes

Reaction equation

HRID 1619979 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([C:17]4[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=4)[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1.C(O)C>O>[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([C:17]4[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=4)[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:5]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 8083MorpholineHCID 179935426-[2-(2,6-dichloro-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Product 1

HCID 866890706-[2-(2-chloro-6-morpholin-4-yl-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.1 g (2.9 mmol) 6-[2-(2,6-dichloro-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, 1 ml morpholine and 50 ml of ethanol are refluxed together for 3 h, then the solv. is eliminated by rotary evaporation i.V., the residue is stirred with water and filtered off. The crude product is recrystallised from aqueous isopropanol.

Workup

  1. filtrationfiltered off
  2. customThe crude product is recrystallised from aqueous isopropanol

Sources & evidence

ORD record
ord-fae0d78418c94f6e919393034d5d009a
Source dataset
uspto-grants-2014_07
Patent number
US08772323B2

Reaction notes

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