HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[2-(4-aminomethyl-phenyl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[6-(4-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-benzonitrile | HCID 67461007 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 6-[2-(4-aminomethyl-phenyl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one | HCID 67462517 | — |
Reaction Steps
100 mg (303 μmol) 4-[6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-benzoxazol-2-yl]-benzonitrile, 10 mg Raney nickel and 20 ml of methanolic ammonia are hydrogenated at RT and 3.45 bar hydrogen pressure for 4 h. Then the mixture is neutralised with conc. hydrochloric acid and the solv. is eliminated from the reaction mixture by rotary evaporation in vacuo. The residue is purified by RP-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-a5243a2f870a41a78727d44bdb1c8d35 |
| Source note | uspto-grants-2014_07 |