HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 67461269, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66706134 | HCID 66706134 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67461269 | HCID 67461269 | — |
Reaction Steps
1 g (4.2 mmol) 1-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridine-hydrochloride and 0.9 g (4.2 mmol) R-4-tert-butoxy-2-cyclopropyl-4-oxobutanoic acid is taken up in 10 ml DMF and combined successively with 2.4 ml TEA and 1.9 g HATU. It is stirred for 30 min. at RT. The solvent is eliminated, the residue is taken up in dichloromethane and shaken 1× with water and 1× with 5% K2CO3 solution. Org. phase separated off and evaporated down. The residue is purified on silica gel (eluant: cyclohexane/EA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772323B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1d1a7201ee984068ba053872e6cad4e2 |
| Source note | uspto-grants-2014_07 |