HCID 67461269, compound → HCID 67467972, compound

Participants

Reaction Conditions

Reaction Steps

1.4 g (3.6 mmol) tert-butyl 3-cyclopropyl-4-(2-phenyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)-4-oxobutanoate are mixed with 150 ml of 1.25 M HCl and stirred for 8 h at 60° C. The mixture is evaporated down and the residue is taken up in dichloromethane. It is filtered to remove the precipitate and the filtrate is evaporated down. This yields 650 mg of colourless resin which is dissolved in 10 ml MeOH and combined with 1 ml 2M trimethylsilyl-diazomethane solution in hexane while being cooled to −5° C. The yellow solution is left overnight with stirring while the ice bath is heated. The solvent is eliminated and the residue is reacted in the following step without any further purification.

Provenance & Evidence