Water → HCID 67465258, compound

Participants

Reaction Conditions

Reaction Steps

550 mg (1.75 mmol) 6-(6-chloro-pyridazin-3-yl)-2-thiophen-2-yl-benzoxazole in 15 mL glacial acetic acid are placed under protective gas in a pressurised vessel, 173 mg (2.11 mmol) sodium acetate are added and the mixture is stirred for 4 days at 120° C. The reaction mixture is combined with H2O and extracted with DCM. The solv. of the org. phase is eliminated i.V. The residue is suspended in ACN and a solid is suction filtered. The solid is suspended in DCM, stirred for 2 h at RT and suction filtered again.

Provenance & Evidence