HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 7-Hydroxychromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Hydroxycoumarin | HCID 13650 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Product | 7-Hydroxychromanone | HCID 298130 | — |
Reaction Steps
A solution of hydroxycoumarin (2.0 g, TCI) in anhydrous THF (50 ml) was added with 10% palladium hydroxide/activated carbon (1.0 g, WAKO), and stirred at room temperature for 2 hours under hydrogen atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble matters were removed by filtration through Celite. The solvent was evaporated under reduced pressure to obtain the title compound (2.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772327B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-42b5a6e743ec43ad98e4c4167e7422da |
| Source note | uspto-grants-2014_07 |