HCID 68613896, compound → 2-Methoxy-7-quinolinamine

HRID 1620073Notes

Reaction equation

HRID 1620073 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([N+:13]([O-])=O)=[CH:8][CH:9]=2)[N:4]=1>[Pd].CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([NH2:13])=[CH:8][CH:9]=2)[N:4]=1

Participants

4

Reactant 1

HCID 68613896HCID 68613896, compound

Product 1

HCID 686143122-Methoxy-7-quinolinamineYield 99.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol (10 ml) solution containing 2-methoxy-7-nitroquinoline (33 mg) obtained in the 1st step was prepared and subjected to a hydrogenation reaction (60° C.; 50 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a purple solid of 2-methoxyquinolin-7-amine (28 mg) was thus obtained.

Workup

  1. customobtained in the 1st step
  2. customwas prepared
  3. distillationThen, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-908a47b3dcb84914959a8df31eff6253
Source dataset
uspto-grants-2014_07
Patent number
US08772320B2

Reaction notes

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