反应详情

Sodium methoxide (28% methanol solution) (2 ml) was added to a methanol (2 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (100 mg), followed by stirring at room temperature for 1 hour. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a yellow solid of 3-bromo-2-methoxy-5-nitropyridine (96 mg) was thus obtained.

1. extractionfollowed by extraction with ethyl acetate
2. washThe resultant was washed with saturated saline
3. dry with materialdried over anhydrous sodium sulfate
4. distillationthe solvent was distilled away under reduced pressure