Thionyl Chloride → HCID 68182200, compound

Participants

Reaction Steps

To a stirred solution of (2-(benzylamino)-6-methoxyquinolin-3-yl)methanol SLA 41006 (0.101 g, 0.343 mmol) in dry CH2Cl2 (50 mL) in a 250 mL round-bottomed flask equipped with a magnetic stirrer was added dropwise SOCl2 (0.50 mL, 6.86 mmol). The mixture was stirred for 1 h at RT then concentrated to dryness at 40° C. under vacuum. The residue was then taken up in CH2Cl2 (20 mL) before concentration back to dryness at 40° C. under vacuum (done 3 times) to give N-benzyl-3-(chloromethyl)-6-methoxyquinolin-2-amine hydrochloride SLA 41008 (120 mg, 100% yield) as a yellow solid.

Provenance & Evidence