Thionyl Chloride → HCID 68182129, compound

Participants

Reaction Steps

To a stirred solution of (6-(methylamino)-[1,3]dioxolo[4,5-g]quinolin-7-yl)methanol CCH 34158-2 (1.00 g, 4.31 mmol) in dry CH2Cl2 (20 mL) in a 50 mL round-bottomed flask equipped with a magnetic stirrer was added dropwise SOCl2 (5.0 mL, 68.9 mmol). The mixture was stirred for 2 h at RT then concentrated to dryness at 40° C. under vacuum. The residue was then taken up in CH2Cl2 (15 mL) before concentration back to dryness at 40° C. under vacuum (done 3 times) to give 7-(chloromethyl)-N-methyl-[1,3]dioxolo[4,5-g]quinolin-6-amine hydrochloride CCH 34158B as a yellow solid (1.24 g, 100% yield).

Provenance & Evidence