Thionyl Chloride → HCID 68182244, compound

Participants

Reaction Steps

To a solution of (6-(ethylamino)-[1,3]dioxolo[4,5-g]quinolin-7-yl)methanol RBO 40002 (901 mg, 3.66 mmol) in CH2Cl2 (30 mL) in a round-bottomed flask equipped with a magnetic stirrer was added thionyl chloride (2.65 mL, 36.6 mmol). The mixture was stirring for 3 h at RT, evaporated under vacuum at 45° C. and coevaporated twice with CH2Cl2 (to remove SOCl2) to afford 7-(chloromethyl)-N-ethyl-[1,3]dioxolo[4,5-g]quinolin-6-amine hydrochloride RBO 40004 as a yellow solid (1.01 g, 92% yield).

Provenance & Evidence