HCID 68048507, compound → HCID 86683816, compound

Participants

Reaction Steps

4-(4-chloro-3-ethylphenoxy)-N-(methylsulfonyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzamide (Preparation 22, 335 mg, 0.53 mmol) was dissolved in 4M hydrogen chloride in dioxane (5 mL). The reaction mixture was stirred 3 hours then concentrated in vacuo. The crude residue was dissolved in methanol (5 mL) and 12N aqueous solution of hydrochloric acid (0.5 mL) was added. The reaction mixture was stirred for 18 hours at room temperature. The reaction mixture was concentrated to dryness then the residue was azeotroped with methanol (25 mL). The crude solid was triturated with tert-butyl methyl ether (4 mL) and the suspension was filtered off. The filtrate was washed with tert-butyl methyl ether to afford the title compound as a cream coloured solid (HCl salt, 106 mg, 44%).

Provenance & Evidence