Hydrogen Peroxide → HCID 66666715, compound

Participants

Reaction Steps

Potassium carbonate (0.194 g, 1.40 mmol) was added to a solution of 4-(4-chloro-2-methoxyphenoxy)-3-(2-methoxypyridin-3-yl)benzonitrile (Preparation 2, 0.257 g, 0.701 mmol) in dimethylsulfoxide (6 mL), followed by dropwise addition of 30% hydrogen peroxide aqueous solution (0.422 mL, 14.00 mmol). The mixture was stirred at room temperature for 1 hour, then quenched by addition of saturated aqueous solution of ammonium chloride (20.0 mL) and water (20.0 mL). The pH of the aqueous was adjusted to pH=7 by dropwise addition of saturated aqueous solution of potassium hydrogen sulfate and then extracted with DCM (3×20 mL). The combined organics were washed with brine (50 mL) and filtered to give the title compound as a solid (0.307 g).

Provenance & Evidence