Potassium Carbonate → HCID 66667179, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (0.784 g, 5.68 mmol) and 3-bromo-4-fluorobenzonitrile (0.378 g, 1.89 mmol) was added to a solution of 4-chloro-2-methoxyphenol (0.300 g, 1.89 mmol) in DMSO (7 mL). The reaction was heated at 80° C. for 2 hours, then cooled and left stirring at room temperature for 18 hours. The reaction was diluted with water (70 mL) and extracted with EtOAc (3×50 mL). The combined organics were washed with 1M NaOH aqueous solution (50 mL), brine (2×70 mL) and then dried over sodium sulfate, filtered and concentrated in vacuo to yield the title compound as an off-white solid (0.625 g).

Provenance & Evidence