Potassium Carbonate → HCID 66668517, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (0.622, 4.50 mmol) and 6-isobutoxypyridin-3-ol (Preparation 7, 0.251 g, 1.50 mmol) were added to a solution of 3-bromo-4-fluorobenzonitrile (0.300 g, 1.50 mmol) in DMSO (7 mL). The reaction was heated at 80° C. for a total of 4 hours and then allowed to cool to room temperature. The mixture was diluted with water (50 mL) and extracted with DCM (3×30 mL). The combined organics were washed with brine (2×50 mL), filtered and concentrated in vacuo to yield the title compound as a solid (0.508 g).

Provenance & Evidence