Hydrogen Peroxide → HCID 66667011, compound

Participants

Reaction Steps

Potassium carbonate (0.143 g, 1.0 mmol) was added to a solution of 4-(4-chlorophenoxy)-3-(3-methoxypyridin-2-yl)benzonitrile (Preparation 12, 0.175 g, 0.52 mmol) in DMSO, followed by dropwise addition of 30% hydrogen peroxide aqueous solution (3.1 mL, 3.1 mmol). The mixture was stirred at room temperature for 1.5 hours. The reaction was quenched with aqueous potassium hydrogen sulfate (30 mL) and extracted with DCM (3×30 mL). The organic layer was washed with water (2×30 mL), dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a white solid (0.269 g). This was taken to the next step without further purification.

Provenance & Evidence