Lithium Hydroxide → 4-(4-Chloro-2-methoxyphenoxy)-2-fluoro-5-(2-methoxypyridin-3-yl)benzoic acid lithium salt

Participants

Reaction Steps

Aqueous lithium hydroxide solution (1M, 0.57 mL, 0.57 mmol) was added to a solution of methyl 4-(4-chloro-2-methoxyphenoxy)-2-fluoro-5-(2-methoxypyridin-3-yl)benzoate (Preparation 16, 0.0477 mg, 0.114 mmol) in THF (2.3 mL) and stirred for 72 hours at room temperature under a nitrogen atmosphere. The reaction was then concentrated in vacuo to afford the title compound as a white solid (0.070 g).

Provenance & Evidence