Hydrogen Peroxide → HCID 66666483, compound

Participants

Reaction Steps

A solution of 30% aqueous hydrogen peroxide (1 mL, 7.6 mmol) was added dropwise to a suspension of 3-(2-methoxypyridin-3-yl)-4-phenoxybenzonitrile (Preparation 20, 0.23 g, 0.76 mmol) and potassium carbonate (0.64 g, 4.6 mmol) in DMSO (3 mL). The reaction mixture was stirred for 2 hours at room temperature, then quenched with aqueous sodium thiosulfate solution (10% w/v, 10 mL) and extracted with EtOAc (50 mL). The organic layer was dried over sodium sulfate and the solvent removed in vacuo to afford the title compound as a pale yellow solid (0.2 g).

Provenance & Evidence