Lithium Hydroxide → HCID 66871907, compound

Participants

Reaction Steps

1.6 ml (1.6 mmol) of an aqueous solution of lithium hydroxide having a concentration of 1N are added to a solution of 450 mg (1.1 mmol) of methyl(S)-3-(4-benzyloxybenzenesulfonylamino)-2-piperidin-1-ylpropanoate in 15 ml of tetrahydrofuran and 0.5 ml of water. After stirring at ambient temperature for 18 h, the tetrahydrofuran is evaporated off under vacuum and then 1.8 ml of an aqueous solution of acetic acid having a concentration of 1N and 15 ml of water are added. The product precipitates and is filtered off. 420 mg (98%) of (S)-3-(4-benzyloxybenzenesulfonylamino)-2-piperidin-1-ylpropanoic acid are obtained in the form of a white solid.

Provenance & Evidence