Cesium carbonate → HCID 67495016, compound

Participants

Reaction Steps

420 mg (1.3 mmol) of cesium carbonate and then 0.2 ml (1.3 mmol) of 1-bromomethyl-4-fluorobenzene are added to a solution of 400 mg (1.2 mmol) of methyl(S)-3-(4-hydroxybenzenesulfonylamino)-2-piperidin-1-ylpropanoate in 10 ml of acetone. After stirring at ambient temperature for 18 h, the reaction medium is filtered and then the filtrate is concentrated under vacuum. The crude product is purified by chromatography on silica gel, elution being carried out with a 70/30 heptane/ethyl acetate mixture. 460 mg (87%) of methyl(S)-3-[4-(4-fluorobenzyloxy)benzenesulfonylamino]-2-piperidin-1-ylpropanoate are obtained in the form of a white solid.

Provenance & Evidence