Hydrochloric Acid → HCID 86664941, compound

Participants

Reaction Steps

0.4 ml (2.0 mmol) of a solution of isopropanolic hydrochloric acid having a concentration of 5-6N is added to a solution of 400 mg (0.8 mmol) of (S)—N-hydroxy-3-[4-(2-methylquinolin-4-ylmethoxy)-benzenesulfonylamino]-2-piperidin-1-ylpropionamide (prepared as described in example 8) in 8 ml of isopropanol. The reaction medium is stirred at ambient temperature for 2 h and then filtered. The residue obtained is recrystallized from a 10/1 isopropanol/water mixture, filtered and dried under vacuum. 260 mg (56%) of (S)—N-hydroxy-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]-2-piperidin-1-ylpropionamide dihydrochloride are obtained in the form of a white solid with a melting point of 188° C.

Provenance & Evidence