Hydrochloric Acid → HCID 71626828, compound

Participants

Reaction Conditions

Reaction Steps

103 mg of (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)-acetate (I-2) was dissolved in 6 ml of diethyl ether, and stirred in an ice-salt bath at −10° C. A hydrogen chloride saturated ethanol solution (0.2 ml) was added slowly dropwise, till the system reached about pH 2, at which a white solid was precipitated immediately. It was stirred for 5 min, allowed to stand, quickly filtered under a nitrogen atmosphere, and washed with a suitable amount of diethyl ether. The resulting solid was dried in vacuum to obtain the I-2 hydrochloride (101 mg, white solid). Yield: 90%, and melting range: 100-120° C.

Provenance & Evidence