Hydrogen chloride-ethyl acetate → HCID 178482469, compound

HRID 1620468Notes

Reaction equation

HRID 1620468 reaction equation
[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[ClH:23].C(OCC)(=O)C>O1CCCC1.CO>[ClH:23].[ClH:23].[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178482474HCID 178482474, compound

Product 1

HCID 178482469HCID 178482469, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of tert-butyl 4-{(Z)-[4-(methylamino)-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (1.27 g) in tetrahydrofuran/methanol (6 mL/6 mL) was added 4M hydrogen chloride/ethyl acetate solution (5.85 mL), and the reaction mixture was stirred at 80° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (1.02 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-3ee7f2a319124748babbb23808b54c5c
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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