Fumaric Acid → HCID 178456903, Verbindung

HRID 1620501Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620501
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[C:15]2/[C:16]([NH:21][CH2:22][C:23]#[CH:24])=[N:17][C:18](=[O:20])[S:19]/2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29]>C(O)C>[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[C:15]2/[C:16]([NH:21][CH2:22][C:23]#[CH:24])=[N:17][C:18](=[O:20])[S:19]/2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 444972Fumaric AcidHCID 178456901HCID 178456901, Verbindung

Produkt 1

HCID 178456903HCID 178456903, VerbindungAusbeute 56,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a solution of (5Z)-5-[(1-benzylpiperidin-4-yl)methylidene]-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one (155 mg) in ethanol (4 mL) was added a solution of fumaric acid (53 mg) in ethanol (4 mL). The reaction mixture was stirred at room temperature for 1 hr, the solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate. The obtained powder was recrystallized from ethanol/diisopropyl ether to give the title compound (118 mg).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customThe obtained powder was recrystallized from ethanol/diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-2e4817d83a1d438f805b990aa9e668bd
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

Notizen zur Reaktion

Wird geladen…