Sodium cyanoborohydride → HCID 68468480, compound

Participants

Reaction Steps

To a solution of 3-tert-butyl 7-methyl 9-oxo-3-azabicyclo[3.3.1]nonane-3,7-dicarboxylate (22.1 g) in THF (372 mL) was added p-toluenesulfonylhydrazide (16.6 g). The reaction mixture was stirred at room temperature for 2 hr, sodium cyanoborohydride was added. The mixture was stirred at 65° C. for 16 hr, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (9.50 g).

Provenance & Evidence