Fumaric Acid → HCID 178456911, compound

Participants

Reaction Steps

To a solution of (5Z)-4-(prop-2-yn-1-ylamino)-5-({1-[4-(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-1,3-thiazol-2(5H)-one (650 mg) in ethanol (5 mL) was added a solution of fumaric acid (189 mg) in ethanol (20 mL). The reaction mixture was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from ethanol/heptane to give the title compound (631 mg).

Provenance & Evidence