Fumaric Acid → HCID 178525528, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(oxetan-3-ylamino)-1,3-thiazol-2(5H)-one (1.5 g) in ethanol (10 mL) was added a solution of fumaric acid (353 mg) in ethanol (10 mL). The reaction mixture was stirred at 80° C. for min, the solvent was evaporated under reduced pressure, and the residue was recrystallized from ethanol/heptane to give the title compound (1.22 g).

Provenance & Evidence