4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178484551, compound

HRID 1620550Notes

Reaction equation

HRID 1620550 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH3:8])[CH2:5][CH2:6][OH:7].S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[OH:7][CH2:6][CH2:5][N:4]([CH3:8])[CH2:3][CH2:2][NH:1][C:10]1[CH2:14][S:13][C:12](=[O:15])[N:11]=1

Participants

4

Reactant 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 108878812-((2-Aminoethyl)(methyl)amino)ethan-1-ol

Product 1

HCID 178484551HCID 178484551, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-[(2-aminoethyl)(methyl)amino]ethanol (1.00 g) in ethanol (30 mL) was added 4-thioxo-1,3-thiazolidin-2-one (1.07 g). The reaction mixture was stirred at room temperature for 3 days, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate) to give the title compound (1.71 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (NH, methanol/ethyl acetate)

Sources & evidence

ORD record
ord-d6f4119cf343419884cc51fffc28c12d
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

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