反应详情

温度

70 °C

To a solution of 1-[2,4-bis(trifluoromethyl)phenyl]ethanone (10.0 g) and piperidin-4-ylmethanol (5.40 g) in THF (368 mL) was added titanium (IV) isopropoxide (34.6 mL). The reaction mixture was stirred at 70° C. overnight, and poured into ice-cooled saturated aqueous sodium hydrogen carbonate solution and the insoluble material was filtered through celite. The organic layer of the filtrate was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound so (12.6 g).

1. additionpoured into ice-
2. filtrationthe insoluble material was filtered through celite
3. customThe organic layer of the filtrate was separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvent was evaporated under reduced pressure