4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518133, compound

HRID 1620591Notes

Reaction equation

HRID 1620591 reaction equation
[CH:1]1([C:4]#[C:5][CH2:6][NH2:7])[CH2:3][CH2:2]1.S=[C:9]1[CH2:13][S:12][C:11](=[O:14])[NH:10]1>C(O)C>[CH:1]1([C:4]#[C:5][CH2:6][NH:7][C:9]2[CH2:13][S:12][C:11](=[O:14])[N:10]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 22136558HCID 22136558, compound

Product 1

HCID 178518133HCID 178518133, compoundYield 88.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3-cyclopropylprop-2-yn-1-amine (4.61 g) in ethanol (50 mL) was added 4-thioxo-1,3-thiazolidin-2-one (3.24 g), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (4.20 g).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

Sources & evidence

ORD record
ord-04713f8530c647719b4a53a072a075d6
Source dataset
uspto-grants-2014_07
Patent number
US08772277B2

Reaction notes

Loading…