HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1620600Generated: October 31, 2026
Piperidinium acetate → HCID 178448896, compound
https://huagongshe.com/reaction/1620600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidinium acetate | HCID 3014295 | — |
| Reactant | 1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde | HCID 86678663 | — |
| Reactant | 4-(but-3-ynylamino)-5H-1,3-thiazol-2-one | HCID 178448894 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178448896 | HCID 178448896 | 37.5% |
Reaction Steps
To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (1.35 g) and 4-(but-3-yn-1-ylamino)-1,3-thiazol-2(5H)-one (1 g) in 2-propanol (20 mL) was added piperidinium acetate (0.58 g). The reaction mixture was stirred at 80° C. for 6 hr and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and recrystallized from ethyl acetate/heptane to give the title compound (0.73 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08772277B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-a5993edea8bb489db3764d7726bf8cdf |
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| Source note | uspto-grants-2014_07 |
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